Interaction of short-term depression and firing dynamics in shaping single neuron encoding

Interaction of short-term depression and firing dynamics in shaping single neuron encoding

Blog Article

We investigated how the two properties short-term synaptic depression of afferent input and postsynaptic firing dynamics combine to determine the operating mode of a neuron.While several computational roles have been ascribed to either, their interaction has not been studied.We considered two types of short-term synaptic dynamics (release-dependent and release-independent depression) and two classes of firing dynamics (regular firing and firing with spike-frequency adaptation).

The input-output transformation of Pain Relief the Colognes four possible combinations of pre- and postsynaptic dynamics was characterized.Adapting neurons receiving input from release-dependent synapses functioned largely as coincidence detectors.The other three configurations showed properties consistent with integrators, each with distinct features.

These results suggest that the operating mode of a neuron is determined by both the pre- and postsynaptic dynamics and that studying them together is necessary to understand emergent properties and their implications for neuronal coding.